• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    It is a valve, in particular sample introduction valve, for a device (1) for synthesis, analysis and / or separation purposes with at least three fluid ports (3 ', 4', 5 ', 6', 7 ', 7 "), with a Housing (8) as a valve member and with a valve body (9) as another valve member for selectively connecting the fluid ports (3 ', 4', 5 ', 6', 7 ', 7 ") over at least one at least partially by sealing surfaces ( 10 ', 11', 12 ') between the housing (8) and valve body (9) limited flow channel (10, 11, 12), said housing (8) and / or valve body (9) are mounted relative to each other movable. In order to provide a one-way valve, it is proposed that, depending on a relative position (9 '), in particular of the valve body (9), at least one valve part (8 or 9) adjoining the sealing surface (10', 11 ', 12') and having a plastic material ) is plastically deformable, in order to be able to withstand liquid pressure in this relative position (9 ') in particular of the valve body (9) increased pressure loads in the flow channel (10, 11, 12).
    公开号:AT511185A1
    申请号:T278/2011
    申请日:2011-03-02
    公开日:2012-09-15
    发明作者:
    申请人:Argos Zyklotron Betr S Gesmbh；
    IPC主号:
    专利说明:

    -1 - (00 026PAT) jel
    The invention relates to a valve, in particular sample introduction valve, for a device for synthesis, analysis and / or separation purposes with at least three fluid connections, with a housing as a valve member and with a valve body as another valve member for selectively connecting the fluid connections via at least one at least partially by sealing surfaces between the housing and the valve body limited flow channel, said housing and / or valve body are mounted to be movable relative to each other.
    In sample separation devices, for example in a HPLC (High Performance Liquid Chromatography) device, it is known for selecting different columns of a fluid sample phase to use a valve, in particular a sample introduction valve (DE102008042252A1). In this case, pumps for moving the mobile phase can generate a pressure of up to 1000 bar, so that the sample feeding valve must meet considerable material and leakage requirements. Therefore, complex and relatively expensive valve designs are known from the prior art, whereby these valves are denied use as a one-way valve. A repeated use of the valves, however, disadvantageously requires a considerable cleaning effort. Especially the latter is of crucial importance for the result of the sample separation device, so that the sample loading valve for device for synthesis, analysis and / or separation purposes plays a special role.
    It is therefore the object of the invention to provide a valve for a device for synthesis, analysis and / or separation purposes of the kind described in the introduction.
    REPLACED * »·» # * * * * ·
    2 structurally that a one-way valve can be made possible with a constructive simplicity and thus low cost. In addition, a cleaning of the valve should no longer be necessary.
    The invention solves this problem in that depending on a relative position, in particular of the valve body at least one adjacent to the sealing surface and a plastic material exhibiting valve member is formed plastically deformable to withstand liquid pressure in this relative position, in particular the valve body increased pressure loads in the flow channel can.
    Is in response to a relative position, in particular of the valve body at least one adjacent to the sealing surface and a plastic material exhibiting valve member formed plastically deformable, then a particularly pressure-resistant valve can be created in a structurally simple manner. This irreversible deformation of the plastic can namely be used to withstand liquid pressure in this relative position (relative to other relative positions, in particular of the valve body relative to the housing) increased pressure loads in the flow channel, so that even tolerances related to craft can be compensated.
    Such a valve can therefore ensure transmission of high pressures at least in a relative position, in particular of its valve body, so that a stable flow channel can be made available in order, for example, to transfer a mobile phase into a column. It is irrelevant to the ^ invention, whether the valve member, the housing or even provided between the valve member and / or the housing seal the plastic deformation of the plastic material passes through to create a pressure-resistant and dense flow channel or a sturdy valve to guarantee. The fact of the possible loss of function of the valve by its irreversible deformation plays a minor role in the invention - after the valve has passed its high-pressure transmission of the mobile phase its function for synthesis, analysis and / or separation purposes. By virtue of this option of permitting plastic deformation, however, the valve according to the invention can be used
    FOLLOW-UP - 3 are kept very simple and therefore cost compared to known valves, so that the possibility of a one-way valve can open. Elaborate cleaning of the valve can thus be omitted, which significantly simplifies the processes for synthesis, analysis and / or separation purposes. In addition, by means of a one-way valve, the risk of falsification of the results due to contamination can be kept small, which can improve the stability of the methods and devices. Therefore, the valve according to the invention is characterized not only by its constructive simplicity and cost-effectiveness, but can also significantly simplify the handling of a device for synthesis, analysis and / or separation purposes when used as a one-way valve.
    Particularly simple handling conditions may result if the valve body is rotatably mounted in the housing via a screw connection. In particular, the degree of plastic deformation can be adjusted by the pitch of the screw in a simple manner, which ensures a reproducible same relative position of the valve body at its high pressure position. In addition, such a rotary valve also opens up a constructive simplicity, because the end face of the valve body or its shell sides can be used for this purpose.
    If the valve body is formed at least partially plastically deformable, then the design effort can be further reduced by the guide is used to provide precisely that sealing surface for a plastic deformation, which is to limit the flow channel with increased pressure resistance. In addition, the valve body is relatively easy to manufacture and is usually not particularly dependent on other valve parts when assembling the valve. The associated reduced production costs can further ensure a reduction in production costs, so that the valve according to the invention can also be suitable as a one-way valve.
    If the valve body rotatably mounted in the housing has at least one end-side recess for at least one flow channel, then, in spite of plastic
    POSSIBLE * * • * c * • * * * «« ··· ♦ · * · • * c * • * · * · «·· ** ♦ ·
    -4 -
    Deformations in the area of the sealing surface are ensured for a stable flow channel. Dimensional changes at the interfaces of the valve parts can namely be absorbed in a simple manner from the flow channel, without disadvantageous to be expected with a closure of this channel.
    A particularly tight connection between the housing and the valve body can be created if the valve body forms at least one plastically deformable sealing lip, which adjoins at least one sealing surface. In addition, by this one-piece construction of the valve body with its sealing lip (no seal to be used more necessary) the design effort and thus the cost of the one-way valve can be reduced. In addition, it can be ensured in this way for a sufficient plastic deformability in the region of the sealing surface, without having to expect an interruption of the flow channel. The stability of the valve can thus be significantly increased.
    Simple construction conditions and high chemical resistance arise when the housing and / or the valve body made of polyetheretherketone (PEEK). In addition, this can be a plastic deformation of both adjacent valve parts are possible, creating a particularly liquid-tight connection can be created, high liquid pressures can therefore be taken without further constructive measures from the valve, making them for device for synthesis, analysis and / or separation purposes especially suitable.
    In order to avoid fittings for the connection of hose lines to the valve, the valve may have a second divided, the housing at least in the area of the liquid connections comprehensive bushing, which in particular aligned with the insertion guides of the liquid connections shots for connecting elastic hose lines forms. The hose lines can thus be taken up and held by the ring, with the aid of the elastic widening of the hose lines under pressure loading a liquid-tight assembly later • • «« · · · «t * ·· * · · · * · *
    ge the hose lines on the valve is possible. A particularly inexpensive valve can thus be created.
    If the receptacles have surface structures for holding the accommodated hose lines, holding the hose lines can be ensured even in the case of high pressure loads in a simple, constructive and cost-effective manner. In addition, it can be used to further improve the resistance of the valve to high pressure loads. Simplified design conditions arise when a holding thread forms such surface structures that can be pressed into the elastic hose lines, for example.
    The invention has been particularly distinguished when this valve is used as a one-way valve in a high performance liquid chromatography (HPLC) apparatus. Elaborate cleaning of the valve can thus be omitted, whereby such methods can be particularly easy to handle and reliable in their results.
    In the figures, for example, the subject invention is illustrated using an exemplary embodiment. Show it
    1 shows a device for synthesis, analysis and / or separation purposes with the valve according to the invention in its "Inject" position,
    2 is a sectional view of the valve of FIG. 1 in its "load" position,
    3 is a sectional view of the valve of FIG. 1 in its "Inject" position with a plastic deformation of a valve member,
    4 is an end view of the valve body,
    Fig. 5 is an enlarged view of a detail section through the valve body of Fig. 4 and
    Fig. 6 is a partially torn plan view of the valve without valve body.
    The valve 2 shown in Fig. 1, for example, in connection with a device 1 for high performance liquid chromatography HPLC is connected to a plurality of hose lines 3, 4, 5, 6 and 7. For this purpose, the Venus
    | REPLACED -6- ti! 2 a plurality of liquid connections 3 ', 4', 5 ', 6', 7 'and 7 ", which are provided on the housing 8. In the housing 8, a relative to the housing 8 movably mounted valve body 9 is provided, as can be seen in Fig. 2. For example, a hose 5 is provided which is connected to a waste container 5 ". Based on its relative pitch 9 ', 9 ", the fluid ports 3', 4 ', 5', 6 ', 7' and 7" can be selectively connected, with a relative position 9 'in Fig. 1 and another relative position 9 " can be recognized in Fig. 2. The relative position 9 "is required in order to be able to give up the sample via the hose line 6 to the loop line 7 (" load "). Flow channels 10, 11, 12 result for this purpose between the respective fluid ports 3 ', 4', 5 6 ', T and 7 ", wherein these flow channels 10, 11, 12 also by sealing surfaces 10', 1112 'between the housing 8 and Limited valve body 9. These sealing surfaces 10 ', 11', 12 'can be seen in particular in Figures 3, 4 and 5, which have been the sake of clarity, as a connecting surface of the cooperating therewith valve parts 8, 9 have been marked. At low pressure requirements on the valve 2, a low surface pressure between the valve parts or between the housing 8 and valve body 9 at the sealing surfaces 10 ', 11', 12 'has been found to be sufficient. It is conceivable to create such a low surface pressure and elastic deformation of the valve parts 8 and / or 9 conceivable. For example, such a low surface pressure is sufficient when the valve in the "load" starting position (relative position 9 ") is brought, because here only low pressures must be withstood. However, if increased pressure requirements of the flow channels 10, 11, 12 are to be withstood, which is necessary for controlling a 200 bar HPLC purification pressure, for example, it is known that considerable design effort is required. Currently known valves are therefore not suitable as a one-way valve, especially when in the direction of a plastic material for the valve parts 8 and 9 is thought, so as to provide a cost-effective valve 2. According to the invention, these disadvantages are overcome by forming in dependence on a relative position 9 'of the valve body at least one of the sealing surface 10', 11 ', 12' adjacent and a plastic material exhibiting valve member 8 and / or 9 plastically deformable. According to FIG. 3, it can be seen that the valve body 9, as a valve part, is a
    -6-REPAYMENT • • Μ Μ ·· * ···
    ner plastic deformation 13 subject. By means of this plastic deformation 13, in this relative position 9 'relative to other relative positions 9 "of the valve body 9, increased pressure loads in the flow channel 10, 11 and / or 12 can be withstood in a liquid-tight manner. This is particularly important in the case of the flow channels 10 and 11, because here the pump 14 has to press the liquid (sample) into a column 15 at high pressure via the loop line 7 (sample loop) ("inject" position of the valve 2). Since this represents the end position of the valve 2, its plastic deformation 13 and thus its loss of function are irrelevant. It is essential, however, that a one-way valve 2 can be created by the simple construction that no more cleaning is needed and thus is particularly advantageous over the prior art.
    The valve body 9 is rotatably mounted in the housing 8 via a screw 16 so as to allow in a structurally simple manner different relative positions 9 ', 9 "of the valve body 9 relative to the housing 8. In particular, however, a reproducibly increasing surface pressure on the sealing surfaces 10 ', 1T and 12' can be made possible via the screw connection 16. Among other things, this leads to the fact that a reproducible plastic deformation for a dense flow channel can be ensured. The valve 2 can thus be characterized by cost-effectiveness and precision as well as by stability.
    Because of the simple production, the valve body 9 has end-side recesses 17, 18, 19 for the flow channels 10, 11 and 12, as can be seen from FIG. 4. Thus, despite plastic deformation in the region of the sealing surfaces 10 ', 1T and 12' stable flow channels 10, 11 and 12 can be ensured.
    The risk of interruption of a flow channel 10, 11 or 12 by a plastic deformation in the region of its sealing surface 10 ', 1T and 12' can be significantly reduced if the valve body 9 forms a plastically deformable sealing lip 20 which is connected to the sealing surface 10 '. connects, as this particular of FIG. 5
    REPLACED «·« · * # * · * * · ·
    -8- can be taken. In FIG. 4 it can be seen that this sealing lip 20 is also provided in the other flow channels 11 and 12. In addition, the possibilities for plastic deformability of the valve body 9 can be adjusted in a simple manner via the configuration of the sealing lip 20. In addition, the valve body 9 and the sealing lip 20 are integrally formed, so that constructive simplicity exists, especially if the entire valve body 9 (with its sealing lip) consists of a plastic material and can be produced for example by an injection molding process in one process step.
    Polyetheretherketone (PEEK) has been found to be a plastic material for the housing 8 and the valve body 9, to provide a suitable and inexpensive sample introduction valve 2 for a high performance liquid chromatography (HPLC) apparatus 1.
    To connect the elastic hose lines 3, 4, 5, 6 and 7, a sleeve 22 is provided around the housing 8, wherein for simplicity, only one hose line 6 has been shown in FIG. The bushing 22 is divided into two parts - indicated by separating surface 22 'and / or separating surface 22 "designed so that it can be easily removed from the housing 8. In particular, the separating surface 22 "is recognizable by the fact that the elevation runs along this separating surface 22" and thus no cutting lines can be seen in this crack. In particular, the separating surface 22 "allows easy connection of the hose lines 3, 4, 5, 6 and to the valve 2. The sleeve 22 is aligned with the plug-in guides 23 of the liquid connections 3 ', 4', 5 ', 6', 7 ' , 7 "directed receptacles 24 for connection of the elastic hose lines 3, 4, 5, 6, 7. In particular, the separation 22 "of the sleeve 22 in the plane of the receptacle 24 is for easy connection of the hose lines 3, 4, 5, 6, 7 of advantage.
    Characterized in that the elastic hose lines 3, 4, 5, 6 and 7 expand under pressure loading, as can be seen on the basis of the hose 6, a liquid-tight connection of these can be made possible to the valve 2. The bush 22 now holds the hose line 3, 4, 5, 6 and 7 on the valve 2 by
    FOLLOW-UP ·· V * ··· * * ·············································································· Recordings 24, each with a holding thread 25 as a surface structure for hooking are provided with the respectively received elastic hose line 3, 4, 5, 6 and 7 respectively. This is particularly advantageous if the hose lines 3, 4, 5, 6, 7 are made of a plastic material. NACHGEREiC! ΪΤ
    权利要求:
    Claims (9)
    [1]
    Patent Attorney Dipl.-Ing. Friedrich Jell Hittmairstrasse 11, A-4020 Linz (00 026PAT) Claims: 1. Valve, in particular sample introduction valve, for a device (1) for synthesis, analysis and / or separation purposes with at least three fluid connections (3 ', 4', 5 ', 6', 7 ', 7 ") having a housing (8) as a valve member and having a valve body (9) as another valve member for selectively connecting the fluid ports (3', 4 ', 5', 6 ' , T, 7 ") via at least one at least partially by sealing surfaces (10 ', 1112') between the housing (8) and valve body (9) limited flow channel (10, 11, 12), said housing (8) and / or valve body ( 9) are mounted movably relative to each other, characterized in that in dependence on a relative position (9 ') in particular of the valve body (9) at least one of the sealing surface (10', 1 T, 12 ') adjacent and a plastic material exhibiting valve member (8 or 9) formed plastically deformable i St in order to be able to withstand liquid pressure in this relative position (9 ') in particular of the valve body (9) increased pressure loads in the flow channel (10, 11, 12).
    [2]
    2. Valve according to claim 1, characterized in that the valve body (9) in the housing (8) via a screw connection (16) is rotatably mounted.
    [3]
    3. Valve according to claim 1 or 2, characterized in that the valve body (9) is formed at least partially plastically deformable.
    [4]
    4. Valve according to claim 1, 2 or 3, characterized in that in the housing (8) rotatably mounted valve body (9) has at least one end-side recess (17) for at least one flow channel (10, 11, 12).

    NACHGEi -2-
    [5]
    5. Valve according to one of claims 1 to 4, characterized in that the valve body (9) at least one plastically deformable sealing lip (20) is formed, which adjoins at least one sealing surface (10 ', 11', 12 ').
    [6]
    6. Valve according to one of claims 1 to 5, characterized in that the housing (8) and / or the valve body (9) made of polyetheretherketone (PEEK) exist.
    [7]
    7. Valve according to one of claims 1 to 6, characterized in that the valve (2) has a second divided, the housing (8) at least in the region of the liquid connections (3 4 ', 5', 6 ', 7', 7 " ) comprehensive bushing (22), which in particular aligned with the insertion guides (23) of the liquid connections (3 ', 4', 5 ', 6', 7 ', 7 ") directed receptacles (24) for connecting elastic hose lines (3, 4, 5, 6, 7) is formed.
    [8]
    8. Valve according to claim 7, characterized in that the receptacles (24) surface structures, in particular retaining thread (25) for holding the recorded hose lines (3, 4, 5, 6, 7).
    [9]
    9. Use of a valve (2) according to any one of claims 1 to 8 as a one-way valve in a device (1) for high performance liquid chromatography (HPLC). Linz, March 2, 2011 ARGOS Zyklotron Betriebs-GesmbH by:

    , · / &/; / FOLLOW
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3707991A|1971-04-12|1973-01-02|J Shapiro|Remote controlled valve for irrigation systems|
    US3885439A|1973-10-24|1975-05-27|Hoffmann La Roche|Rotating sampling valve|
    SU773359A1|1979-02-19|1980-10-23|Опытное Конструкторско-Технологическое Бюро "Кристалл" При Ленинградском Технологическом Институте Им. Ленсовета|Multiway cock|
    US4464340A|1981-06-15|1984-08-07|Burroughs Wellcome Co.|Dissolution flask|
    US5010921A|1989-07-17|1991-04-30|Spectra-Physics, Inc.|Nonsymmetrical valve|
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    JP2003084001A|2001-09-14|2003-03-19|Kawamura Inst Of Chem Res|Micro fluid device having micro valve mechanism, micro valve mechanism driving apparatus therefor, and flow control method|
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    CN201090731Y|2007-08-27|2008-07-23|程麒|High pressure self-lubricating Y-shaped seal ring|
    DE102008042252B4|2008-09-22|2021-03-25|Agilent Technologies Inc.|Fluid valve with push-pull mechanism|
    WO2010051297A1|2008-10-28|2010-05-06|Waters Technologies Corporation|Techniques for patterning valve components|
    WO2010151440A1|2009-06-26|2010-12-29|Waters Technologies Corporation|Chromatography apparatus having an integrated core|DE102013104404A1|2013-04-30|2014-10-30|Hamilton Bonaduz Ag|Sampler for an analyzer|
    FR3018116B1|2014-02-28|2017-06-16|Horiba Abx Sas|ROTATING SAMPLING VALVE AND DEVICE EQUIPPED WITH SUCH VALVE|
    CN105987201B|2014-08-12|2018-12-04|山东省水利科学研究院|Reversal valve and corresponding reversing pipeline system|
    CN104458978B|2014-10-24|2016-01-13|北京佰纯润宇生物科技有限公司|A kind of five eight logical valves and a kind of tomographic system based on five eight logical valves|
    法律状态:
    2014-10-15| PC| Change of the owner|Owner name: CHRISTOPH MAG. ARTNER, AT Effective date: 20140818 |
    2021-07-15| PC| Change of the owner|Owner name: ARGOS ZYKLOTRON BETRIEBS-GESMBH, AT Effective date: 20210608 |
    优先权:
    申请号 | 申请日 | 专利标题
    ATA278/2011A|AT511185B1|2011-03-02|2011-03-02|VALVE AND USE OF THE VALVE|ATA278/2011A| AT511185B1|2011-03-02|2011-03-02|VALVE AND USE OF THE VALVE|
    PCT/AT2012/050027| WO2012116390A1|2011-03-02|2012-03-01|Valve having a deformable part and use of the valve|
    US14/002,401| US9611942B2|2011-03-02|2012-03-01|Valve having a deformable part and use of the valve|
    JP2013555703A| JP2014508934A|2011-03-02|2012-03-01|Valve with deformable parts and use of the valve|
    EP12718557.7A| EP2681547A1|2011-03-02|2012-03-01|Valve having a deformable part and use of the valve|
    CN2012800114105A| CN103403540A|2011-03-02|2012-03-01|Valve having a deformable part and use of the valve|
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